There is some difference in the numerical result
which various PSA brand systems will determine on the same patient sample. This is of
scientific interest, mostly; but it is of practical interest in that, as always, it means
that laboratorians must be careful.
Certain persons active in
the arena of prostate cancer become nearly hysterical (about 1995) in their zeal that Hybritech is
the only reliable brand system.
Of much greater significance is the diligence, tenacity, freedom
from distractions, and accuracy with which the technologists can exert the quality control system
on the specimen testing in any given lab. What do you know about the minute-to-minute integrity of
the people responsible for your testing?
Our lab specializes in immunotechniques; PSA testing is by such
immunotechniques. We previously used the TOSOH system and published our internal study showing it
to be every bit as reliable as Hybritech (Am. J. Clin. Path 100:319,1993). This system was
subsequently bought by Abbott; and we used it as an Abbott brand. By 2007, even more changes have
We acknowledge with gratitude Hybritech's long-term support of
prostate cancer awareness meetings produced by support organizations such as US TOO. And we are
grateful in behalf of men in general for the boundless energy in favor of prostate cancer awareness
as exhibited by leaders such as our friend Roland Young, of Columbia, S.
BPH, prostate cancer,
prostatitis, urinary retention, cystoscopy, prostate biopsy or TURP, ejaculation, and DRE prostate
exam/massage can all elevate serum total PSA...some doing it just
briefly. When making serial measurements over time, a value change COULD be due to the test being done in different labs or the lab made a test brand change.
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(posted about 1999; latest addition 13 August